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This is the primary driver of GLP-1 weight regain

Medication choice should be individualized, not trend-driven. Up next in this series: Are weight loss medications safe long term and what we actually know from the data

Research shows that behavior change alone rarely maintains GLP-1 weight loss after stoppingapproximately 70% of weight returns despite best efforts

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Some patients lose significant weight without feeling cold, while others experience chills early then warm up as their body stabilizes

But that most GLP-1 RA clinical trials have not lasted for more than a year