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Cells in the body make glutathione to protect themselves from oxidative stress

Goodman-Gruen D et al

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At therapeutic doses it is safe for most people, but acetaminophen metabolism uses glutathione directly, and chronic high dose use is the leading cause of acute liver failure in the United States precisely because it exhausts hepatic glutathione (PubMed PMID: 26041729)

If you are taking glutathione to brighten your skin but spending hours in the sun without protection, you are essentially pulling your body in two different directions

Carter-Su, C., Schwartz, J., & Argetsinger, L