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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

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These kinases inhibit the opening of the mitochondrial permeability transition pore (mPTP), preventing apoptosis and allowing cell survival in cardiomyocytes (Jie et al