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Beverly Tchang, MD, DABOM , Ro Obesity Medicine Advisor and endocrinologist, sums this up well: Compounded semaglutide is not standardizedone compounded semaglutide is not the same as another compounded semaglutide, and none of them have been tested in clinical trials for safety or efficacy. Compounding pharmacies also prepare compounded semaglutide to meet demand and patient needs during drug shortages, which have affected Ozempic and Wegovy on an on-and-off basis since March 2022