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[3] [14] The increased frequency and looser consistency of stools may result from altered gut motility and changes in intestinal fluid secretion

Furthermore, it significantly decreased aldosterone concentrations, a known predictor of increased cardiovascular mortality risk, which would indicate AT1R blockade ( Finally, the prevalence of primary aldosteronism (PA), the most common form of secondary hypertension, is reported to be 11-14% in patients with diabetes and hypertension

Winfrey started taking GLP-1 medication in 2023, then took a one-year break from 2024 to 2025

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