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Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1

When calorie intake drops 30-50% (common on GLP-1 drugs due to appetite suppression), the body increases muscle protein breakdown to meet energy demands

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Lately, these oral hypoglycemic agents, because of their insulinotropic effect, have progressively replaced sulfonylurea as second-line therapy and are also endorsed in the guidelines in triple therapies along with metformin and SGLT-2 inhibitors (5557)

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Short-term storage conditions of peptides: avoid light, 4