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There are safety concerns surrounding compounded semaglutide
The appetite and energy systems that drive obesity are regulated by multiple overlapping hormonal pathways targeting just one of them has inherent limits
Why they matter: Large randomised cardiovascular and renal outcome trials (EMPA-REG OUTCOME, DAPA-HF, DAPA-CKD, EMPEROR-Reduced/Preserved, CREDENCE, EMPA-KIDNEY) consistently showed reductions in heart-failure hospitalisation, progression of chronic kidney disease, and cardiovascular death
Treatment options range from simple monitoring to medication, radiofrequency ablation, or surgery, depending on the nodules size, function, and risk of malignancy
Headaches in idiopathic intracranial hypertension
So, while they show promising results so far, whether this effect translates to humans, needs more research to answer
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