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A more recent study showed that the ependymal zone harbors neural progenitor cells that are vulnerable to acute HSV-1 infection and viral lytic-associated proteins were detected in these cells during latency (Chucair-Elliot et al., 2014)

Rather than reducing demand for orthopedic procedures, these medications may facilitate better patient outcomes, fewer complications, and a shift toward higher-quality, lower-risk surgical care, ultimately benefiting both patients and orthopedic surgeons

doi: 10.1016/j.taap.2012.12.013 Toxicol Appl Pharmacol

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The rationale for combining them, as explored in published research, is potential additive or synergistic engagement of these separate receptor systems