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demonstrated that GLP-1/GLP-1R signalling plays a crucial role in activating signal transducer and activator of transcription 3 (STAT3), which directly promotes human M2 macrophage polarization while inhibiting classically activated M1 macrophages, known for their pro-inflammatory and tissue-destructive properties (44)

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This surge reflects a paradigm shift in how we approach diabetes and obesity management

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doi.org/10.1111/dom.15728 4 Tinsley GM, Nadolsky S