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For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures
Clinicians might be wise to keep patients with type 1 on smaller GLP-1 doses throughout their treatment, Garg says
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Freeland KR, Wolever TM
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