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Treatment of multiple myeloma
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LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al
Epidemiology of CNS infections
While both compounds work through different mechanisms that theoretically could complement each other, the safety, efficacy, and optimal dosing of this combination remain completely unknown
Oral administration of glutathione alone is thought to be ineffective for altering glutathione levels due to hydrolysis during digestion and poor absorption
