weight gain after tirzepatide reddit loss maintenance discontinuing GLP-1 : r/Zepbound If weight loss is one

Am J Physiol Renal Physiol 293:F541F547

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But: GLP-1s help you maintain the calorie deficit required for overall fat loss, which includes visceral abdominal fat (the dangerous kind around your organs) and subcutaneous belly fat (the pinchable kind under your skin)

This is anecdotal territory, not rigorously studied

Receptor Pharmacology and Mechanism of Action IGF-1 LR3 acts via IGF-1R tyrosine kinase receptor IRS-1/PI3K/AKT/mTOR pathway activation

Its important to rotate injection sites with each dose to avoid irritation or skin damage