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B12 also plays a crucial role in maintaining the protective layer around nerves, promoting nerve health, and preventing anemia by supporting red blood cell production

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However, these trials concentrated on cardiovascular outcomes rather than ocular ones, with inconsistent definitions and grading, rendering them insufficient for evaluating the long-term stabilization or enhancement of retinal pathology following an acute reduction in glycosylated hemoglobin (HbA1c)

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Commonly referenced guidance includes: Initial replacement Maintenance For maintenance, the BNF lists adult prophylaxis/maintenance dosing such as 1 mg intramuscularly every 23 months in appropriate cases