Activation of the GLP-1 receptor delays gastric emptying, suppresses appetite, and promotes insulin secretion
Because the medication is taken weekly rather than daily, it simplifies the treatment routine for many individuals
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doi: 10.3389/fmed.2021.777861 26 PabelSHamdaniNLueddeMSossallaS
The lipid tail allows semaglutide to bind reversibly to serum albumin, which slows renal clearance and gives the peptide a half-life of approximately one week, supporting once-weekly subcutaneous dosing in published pharmacokinetic studies