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27 Hence, using Ile 12 in tirzepatide seems not to weaken its GLP-1 activity and to strengthen its GIP activity

Semaglutide is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, suppresses appetite via central nervous system pathways, and delays gastric emptying

Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage

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