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Early pharmacokinetic studies suggested that when standard, unprotected glutathione was ingested, it was rapidly cleaved into its constituent amino acids (glutamate, cysteine, and glycine) by digestive enzymes like $\gamma$-glutamyltransferase and harsh stomach acids

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The tumor suppressor p53 regulates cell cycle progression and apoptosis while orchestrating metabolic reprogramming in malignancies by balancing OXPHOS and glycolysis