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24 In kidney injury, platelet-activating factor (PAF) and PAF-like phospholipids are extracellular mediators of synchronized tubular ferroptosis

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Consistently with its low efficacy in beta-arrestin recruitment, which is involved in receptor endocytosis, the ability of tirzepatide to induce GLP-1R internalization is approximately 40% that of native GLP-1 while its effect on GIPR is similar to native GIP

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