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Funding This work was supported by NSFC (81770776
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Under homeostatic conditions, 15-HpETE-PE is rapidly and specifically metabolized by the GSH-dependent GPX4 to the nonreactive hydroxy derivative 15-HETE-PE (6, 14)
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Consistent with observations made at single wavelengths for this reaction (discussed below), this data fit to k 1 of 730 18 s 1 , and k 2 of 1.46 0.01 s 1 revealing three spectra that represent the spectrophotometric changes associated with the C159S reductive half-reaction (Figure 3A)
& Kurosawa, T
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