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In a study that enrolled 32 610 runners and 14 917 walkers who were followed for 6.2 years, both moderate exercise (walking) and vigorous exercise (running) were associated with a significantly lower risk of cataracts (Williams 2013)

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Synthesis Add 96g of acetic acid to the reaction vessel, add 32g of levulinic acid to dissolve under stirring, when completely dissolved, add 61.5g of acetic anhydride, then raise the temperature to 80 constant temperature reaction for 12 hours, the reaction is completed, in a vacuum of -0.09Mpa, the temperature of 80 below the distillation of acetic acid removal, reduce the temperature to 40 , add 160g of acetone, fully stirred and dispersed for 0.5 hours, reduced temperature to 5 below precipitation of crystals, and held between 0 ~ 5 for 2 hours, filtration and separation, wash the solid with acetone, in a vacuum -0.09 Mpa, dried at 80 , that is to obtain acetyl levulinic acid 36g finished product, yield 88.9%

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termed growth hormone-releasing factor, GRF, in the cited historical study) did