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As depicted in our graphical abstract (Supplementary Fig
While substantial advances have shaped our understanding of ferroptosis 1 , GPX4-restricted immunologic responses remain poorly explored despite reports of inflammatory tissue injury in GPX4-deficient animals 9,11,27
This process requires glutathione (GSH), whose synthesis depends on cysteine availability, primarily supplied through the Solute Carrier Family 7 Member 11 (SLC7A11) (system Xc - ) cystine/glutamate antiporter ( Figure 4 ) (87)
Tadiello A, Longhi S, Moretto M, Ferrarini A, Tononi P, Farneti B, Busatto N, Vrhovsek U, Molin AD, Avanzato C, Biasioli F
It helps to relax the blood vessels and increase blood flow
Use of the Advanced Photon Source was supported by the U.S
