Published investigations report measurable biological signaling changes in controlled human or preclinical settings
[5] Apart from true vitamin B allergy (which is rare), there are no absolute contraindications in the general population, because pyridoxine is an essential nutrient
It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations
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It can be given monthly to young stock to help maintain adequate levels