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In addition, the analgesic effect of melatonin is mediated through activation of supraspinal sites, inhibition of spinal nociception, and modulation of various neurobiological systems, including GABAergic, opioid, and glutamatergic systems [65]

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Bacteriostatic water is superior for multi-dose vial use because it contains 0.9% benzyl alcohol, which inhibits bacterial growth and permits safe storage for 28 days despite repeated needle punctures

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