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Many keep the improvement for months after finishing a protocol, the unusual part of DSIPs clinical record
So, if you only care about living longer, might the benefits of weight loss outweigh the risks of dying on the operating table
Where it works: Liver: Increases hepatic glucose production and fat oxidation (when carbs are low) Adipose tissue: Stimulates lipolysis (breakdown of stored fat into free fatty acids) Brown adipose tissue: Activates thermogenesis (heat production from burning fat) Muscle: May increase fat oxidation during exercise Weight loss contribution: The glucagon component appears to add an additional 2-3% weight loss beyond the GLP-1/GIP combination (24% vs 22% for tirzepatide)
This creates what some clinicians describe as built-in accountability the medication effectively discourages high-fat eating through immediate, uncomfortable consequences
Frontiers in pharmacology, 11 , 41
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