GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]
Understanding these mechanisms is critical before evaluating specific protocols
Lanzaro A, Roche A, Sibanda N, Corbett D, Davis P, Shah M, Pathak JA, Uddin S, van der Walle CF, Yuan X-F, et al
Personalized Treatment Regimen Dosage, frequency and program length are determined according to the provider-approved plan
CJC-1295 / Ipamorelin is typically provided as a subcutaneous injection
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