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doi: 10.1111/j.1524-475X.2008.00395.x 181 DubskMJirkovskABemRFejfarovVSkibovJSchaperNCet al
These medications are intended for long-term use
Everyday Movement Even small things help: Take the stairs Stand up often Do stretches during breaks 3
10.1172/jci113539 338
What this does NOT prove: that it preserves lean mass without resistance training, that it is safe long-term without Phase 3 data, or that results in the trial population (adults with obesity, BMI 30 or above) translate to lean young men
Future randomized, dermatology-specific trials should stratify by obesity and diabetes status, capture early immunologic and imaging biomarkers, and focus on outcomes that matter directly to patients, such as pain, work and school attendance, and procedure burden
