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Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)
doi:10.1111/j.1749-6632.2003.tb03167.x Pfaus JG, Sadiq A, Spana C, Clayton AH
However, tirzepatide seems to be at least as potent as GLP-1 RAs at lowering blood sugar in those with diabetes
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