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In contrast to earlier GLP-1 receptor agonists, which primarily target appetite suppression and glycemic improvement, Retatrutide leverages GCG receptor activation to stimulate lipolysis and elevate basal metabolic rate, thereby contributing to a more pronounced and sustained reduction in adiposity as observed in research models

Curr Diabetes Rep (2018) 18(7):45

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Psychiatry 78 , 702710

Less-selective compounds in the same class (GHRP-2, GHRP-6, hexarelin) cross-activate other endocrine axes alongside GH, which makes them noisier reference tools when researchers want to isolate ghrelin-pathway signalling from confounding hormonal effects