Patients should be counselled about realistic expectations, the commitment required for weekly injections, and the importance of maintaining communication with both their rheumatology and weight management teams throughout treatment
Compounded tirzepatide from licensed 503A pharmacies carries the same active ingredient as Mounjaro, so adverse event profiles are clinically equivalent
Indeed, the combined use of these medications is suggested to be synergistic and, as reported in a recent meta-analysis, superior outcomes with the addition of a GLP-1 RA to SGLT2i can be observed in type 2 diabetes, although observations of cardiovascular and mortality outcomes are limited [29]
The substance is usually administered via injections, either subcutaneously (under the skin) or intramuscularly, with the number of injections varying based on the desired outcome and dosage
2021;371:eabc4552
Funding This work was supported by Statutory Funds of the Laboratory of Immunoendocrinology, Maj Institute of Pharmacology, Cracow, Poland