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The effect was due to on-target inhibition of GPX4 rather than reduction of GSH levels, as, contrary to the marked reduction in GSH observed with L-buthionine-sulfoximine (BSO), we observed only a small reduction with SCLA2 at 10 M and no change at 1 M (Extended Data Fig
doi: 10.1038/s41598-017-09898-4
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Administered once daily, CT-868 aims to maximize both efficacy and tolerability
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