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Constipation Slow transit may prolong intestinal contact with biliary metabolites and increase the opportunity for deconjugation and reabsorption

The following protocols represent commonly used approaches derived from available research and extensive user experience

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Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use