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Other common gastrointestinal effects include: Vomiting (5-24% of patients) Diarrhea (8-30% of patients) Constipation (10-24% of patients) Abdominal pain or discomfort (5-20% of patients) These side effects are typically most pronounced when initiating therapy or increasing doses, and often diminish over time as the body adjusts to the medication

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When people stop these medications, it's not just the weight that can come back there's also a resurgence in inflammation, blood pressure and cholesterol

Blood Pressure & Lipids Patients on these therapies often see a significant drop in systolic blood pressure and improvements in their lipid panels (triglycerides and ApoB), likely due to improved insulin sensitivity