Rapid translocation of nanoparticles from the lung airspaces to the body
Numerous investigational therapies targeting inflammation, oxidative stress, liver regeneration, bile acid signalling, epigenetic regulation, and the gut-liver axis have been evaluated, with largely disappointing results
Amer Assoc Cancer Res 22, 1981
Mast cell activation leads to the release of specific inflammatory mediators such as TNF-, IL-1, IL-8, IL-33, chemokine (C-C motif) ligand 2 (CCL2), CCL3, CCL5, granulocyte macrophage colony-stimulating factor (GM-CSF), VEGF, matrix metalloproteinase (MMPs), ROS, substance P (SP), stem cell factor (SCF), nerve growth factor (NGF), dopamine, transforming growth factor-beta (TGF-), corticotrophin-releasing hormone (CRH), neurotensin, histamine, prostaglandin D2 (PGD2), leukotrienes (LTs), proteases tryptase and chymase based upon the type of mast cells and type of stimuli in the tissues (Gilfillan et al., 2011
A search on PubMed returns many papers on rodents and cell models, and reviews on PubMed Central describe it as a possible therapy rather than a proven one
Focus on brightening, exfoliation, and sun protection
