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Some studies have found participants receiving the high-dose B vitamins had a greater risk of heart attack, stroke and death, compared to those receiving a placebo

[103] Metformin [edit] Reduced serum levels of vitamin B 12 occur in up to 30% of people taking long-term anti-diabetic metformin

For the treatment policy estimand, continuous endpoint analyses were conducted with the use of the analysis-of-covariance method, with randomized treatment as a factor and baseline endpoint value as a covariate

Results vary

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Comparing efficacy on the basis of preclinical 5-Amino-1MQ data would be misleading