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However, excessive ROS accumulation can lead to oxidative damage, disrupting cellular components and ultimately triggering cell death [4]

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Antioxidant Defense Glutathione peroxidases use glutathione to reduce peroxides and limit oxidative damage to proteins, membranes and mitochondria

Importantly, microglia in this activated state also secrete pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which further amplify ROS production and reinforce the inflammatory state

However, its impact was neutralised by performing trim and fill analysis