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16.8% average weight loss at 12 mg 2.0% HbA1c reduction at 12 mg Discontinuation due to side effects: 5.1% at 12 mg notably lower than the obesity-only TRIUMPH trials Dysesthesia also lower in this population The lower side-effect rate in the diabetes population is not fully explained yet
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L-carnitine ameliorates muscle mass atrophy and body weight loss Although our in vitro findings demonstrated a significant impact of L-carnitine on the TNF--induced C2C12 cell cachexia model and provided insight into the specific mechanism, drug metabolism in vivo is complex
Food and Drug Administration (FDA) in 2017 for the treatment of T2D, with clinical use beginning in 2018 [15]
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