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Molecular modelling and mutagenesis studies indicate that agonist positive allosteric modulators target the same general region, but in a distinct sub-pocket at the interface between helices V and VI, which may facilitate the formation of an intracellular binding site that enhances G-protein coupling

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General Features of ATB 0,+ (SLC6A14) ATB 0,+ is a plasma membrane transporter belonging to the SLC6 family that includes amino acid transporters, neurotransmitter transporters, and osmolyte transporters (Pramod et al., 2013)

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