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TAMs, predominantly of the M2-like phenotype, and MDSCs secrete immunosuppressive cytokines (e.g., IL-10, TGF-) that inhibit T cell function and drive immune exhaustion
doi: 10.4093/dmj.2012.36.4.262
In conditions marked by the absence of CBS, Hcy tends to accumulate excessively, leading to hyperhomocysteinemia (HHcy) (Poddar 2021)
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Early preclinical studies in experimental diabetes demonstrated toxicities such as anemia, thrombocytopenia, splenomegaly, lymphadenopathy, lung histiocytosis, mortality with multiple organ pathology, gastrointestinal, and central nervous system toxicity
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