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Conversely, at higher concentrations, this promoting effect is suppressed, indicating a dual regulatory role of bile acids on respiratory immune responses depending on their concentration (110)

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Therefore, a combination of transcellular and paracellular routes for crossing the nasopharyngeal barrier is also possible if the meningococci crossing via the transcellular route induce a sufficient level of inflammation to alter epithelial permeability, allowing other bacteria to follow the paracellular route

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Thus, we multiply the V max values of GCL and GPX by a number, S , where S = 1 for males and S = 1.8 for females

145 KrzystyniakA.BaczynskaE.MagnowskaM.AntoniukS.RoszkowskaM.Zareba-KoziolM.et al (2019)