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Downsides of GLP-1 drugs One of the biggest drawbacks of these drugs is that they have to be taken forever to maintain weight loss
As GLP-1R agonists mediate their appetite-reducing effects within the central nervous system, the trafficking phenotype of exendin-phe1 could result in reduced brain penetration, mitigating against presumed advantageous effects on neuronal GLP-1R desensitization
Understanding the timing and frequency of both medications is important to avoid unnecessary complications
Optimize management of hypertension and hyperlipidemia, which contribute to diabetic eye disease progression
Accessed 12 June 2025
(Source 5) Another option is supplementing with N-acetyl cysteine, a glutathione precursor, which encourages the body to increase glutathione production
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