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References to biological effects are provided for scientific context only and must not be interpreted as claims of therapeutic, diagnostic, cosmetic, or clinical benefit
A meta-analysis of 87,162 patients in 9 clinical trials showed that alogliptin was shown to be a safe drug for diabetic patients with cardiovascular complications [19,20,21]
The sub-30-minute plasma half-life is the pharmacokinetic basis for twice-daily dosing, though no human study has confirmed this produces better outcomes
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The binding of antithrombin III to the endothelial surface is also reduced by homocysteine through inhibition of heparin sulfate expression (Nishinaga et al, 1993)
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