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Thus, it is reasonable to use GLP-1based therapy as add-on therapy to SGLT2i in individuals with T2D, HFpEF, and additional CKM risk factors or related conditions, such as obesity (Section 6.3.1, CKM Syndrome Stage 4 With Obesity and HF), CKD with albuminuria (Section 6.3.3, CKM Syndrome Stage 4 With CKD and HF), MASLD (Section 7.2, Metabolic DysfunctionAssociated Steatotic Liver Disease), and ASCVD (Section 6.2.2, CKM Syndrome Stage 4 With T2D and ASCVD)

This may also explain why participants in the placebo group showed a non-significant reduction in muscle strength parameters, while those in the L-Carnitine group maintained and those in the L-Carnitine-combination group improved muscle strength

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736: Optimizing postpartum care

Mouse carnitineacylcarnitine translocase ( CACT ) is transcriptionally regulated by PPAR and PPAR in liver cells