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Inflammasome activation and the progression of inflammatory bowel disease are modulated by palmitoylation of NLRP3, while inflammasome activation and the severity of dextran sulfate sodium (DSS)-induced colitis in mice are effectively attenuated by pharmacological inhibition of NLRP3 palmitoylation ( Some palmitoylation-related enzymes are important regulators of IBD

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4 (download XLSX Excel workbook with raw data Source Data Extended Data Table 1 (download XLSX Excel workbook with raw data Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

The well-characterized safety profile means that common adverse effects are predictable and manageable

Goat anti-mouse IgG or anti-rabbit IgG (Boster, Wuhan, China) conjugated to HRP was used as the secondary antibody

While not a replacement for mental health treatment, they can support overall wellness