Springer, B., & Thomas, J
Alternatives and Personalized Approaches to GLP-1 Therapy If depression or mood instability emerges during semaglutide treatment, options include dose reduction, switching to a different GLP-1 medication with different pharmacokinetics, or temporarily pausing therapy while addressing the underlying mood disorder with psychiatric support
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Many patients use semaglutide for 12 to 18 months to achieve their target weight, after which the clinical team works with them on a structured maintenance plan that may include continued lower-dose medication, ongoing nutritional support, and behavioral strategies to prevent weight regain
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One study evaluated the efficacy of topical glutathione on improvement in pigmentation