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Supplements that worsen constipation: Calcium supplements (especially calcium carbonate) Aluminum-containing antacids (Maalox, Mylanta) Opioid pain medications (compounding effect with GLP-1) Anticholinergic medications (antihistamines, tricyclic antidepressants) A simple elimination trial: remove dairy and processed grains for 10 days while on Ozempic

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However, oral GLP-1s can cause more noticeable digestive side effects, and some research shows that the injectable version may be slightly more effective for weight loss

When muscle drops too much during weight loss, patients may experience: Reduced strength Lower energy Poorer exercise tolerance Increased frailty risk Greater chance of weight regain Less favorable body shape after weight loss Reduced metabolic flexibility Higher risk of functional decline with aging This is one reason the term skinny fat has become common in wellness conversations

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