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Despite these insights, the incidence of clinically significant muscle wasting attributable to GLP-1RA therapy remains undefined

Any family history of thyroid cancer or pancreatitis

Published in The Lancet

The vestibular disorder finding A large real-world study analyzing 419,497 semaglutide users and 77,259 tirzepatide users found substantially elevated vestibular disorder risk compared to matched controls

Researchers are also investigating whether the effects differ based on baseline drinking severity, metabolic status, and genetic factors related to GLP-1 receptor expression and function

The injections may cause severe allergic reactions in the patient