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J Med Chem 2017;60:7434-46
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While most prescription drugs have little to no brand recognition, these and other GLP-1s have become household names seemingly overnight, and their brand names have become synonymous with weight loss
Safety and Tolerability As with many metabolic therapies, the most commonly reported side effects in the Retatrutide trial included gastrointestinal symptoms such as nausea, diarrhea, constipation, vomiting, and decreased appetite, patterns seen with many gut-hormone modulators
It promotes the macrophage transition from M1 (pro-inflammatory) to M2 (anti-inflammatory)
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