The rapid inactivation of GLP-1 by the enzyme dipeptidyl peptidase IV (DPP-IV) within minutes prompted the development of GLP-1 analogs with prolonged half-lives, which are now approved for the treatment of T2DM and obesity (semaglutide, 160 h half-life)
HOW IT WORKS 1
Using backup contraception during the first month of GLP-1 therapy provides extra reassurance, though it is not universally required
Don't leave the vial sitting open or the needle inserted for longer than necessary
7, 141145.10.1046/j.1365-313X.1995.07010141.x 61 UllmannP.GondetL.PotierS.BachT
Aim for a 20 to 30 gram protein snack within 30 to 60 minutes of feeling the drugs peak effect or before exercise, for example, Greek yogurt with a tablespoon of nuts, a hardboiled egg, and a whole grain cracker, or a protein shake diluted with water