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Step 1: Calculate your basal metabolic rate Your basal metabolic rate, or BMR, represents the calories your body burns at complete rest

The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation

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First, assess the situation: Determine exactly how much extra medication you have taken Note the time of administration Check whether you have taken your other diabetes medications as usual If possible, measure your blood glucose level Contact healthcare services immediately for guidance

Liver enzymes, markers of glycemic control, markers of insulin resistance and advanced biomarkers help to reveal the pathophysiology of MASLD and its progression to T2DM (106)

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