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While studies attempting to localize the pathology in FMS to peripheral tissues have failed in showing any abnormalities in muscle tissue, Staud and coworkers did show that enhanced central pain processing can occur via continued peripheral muscle afferent input, Their study demonstrated that muscle lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in fibromyalgia patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization

Treating hypocobalaminemia (B12 deficiency)

Pain scores decreased by an average of 3.2 points on the standard 10-point scale

GHK-Cu may be the strongest counterpoint

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Angiogenesis Research: Analyzing the formation of new blood vessels, a critical step in tissue repair that is heavily studied in conjunction with this peptide