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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

This is typically observed at doses between 200 to 400 mg/day in healthy young adults, with some degree of individual variation (23, 24)

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Chronic diseases that affect red blood cell production, such as cancer, liver disease, chronic kidney disease, immunodeficiency, HIV infection, and rheumatoid arthritis, impair bone marrow function and result in fewer red blood cells

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et al Sensistivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies